Nuclear energy complements a diverse array of clean energy technologies, but surpasses all others in terms of capacity and reliability. Intense interest in advanced nuclear reactors is underpinned by increases in projected power demands by upwards of 30% in the next decade. The US Department of Energy and its national laboratories are engaged in activities to develop, demonstrate, and deploy advanced nuclear technologies to support traditional grid-scale energy supply; specialised power applications for data centres, remote communities, and disaster response; and for industrial heat to facilitate petrochemical production, steelmaking, hydrogen production, and desalination. This fireside chat will explore the various ongoing activities to engage with international partners and industries to develop and deploy advanced nuclear technologies.